Oxymetazoline Metered Dose Spray: Factors Affecting Delivery Volume
نویسندگان
چکیده
منابع مشابه
Factors affecting total and "respirable" dose delivered by a salbutamol metered dose inhaler.
BACKGROUND Many factors contribute to the high variability of doses delivered to the lungs of patients using metered dose inhalers (MDIs). Relatively little attention has been paid to the contribution to this variability of the way in which the MDI is handled before the inhalation manoeuvre. Instruction leaflets often recommend procedures at odds with those used for in vitro testing of the devi...
متن کاملA Novel Metered Dose Transdermal Spray Formulation for Oxybutynin
The objective of the present work was to develop a metered dose spray formulation for transdermal delivery of oxybutynin and to carry out the in vitro characterization of the optimized formulation. Oxybutynin release from a series of ethanol/acetone/methylal based formulations was assessed in vitro and the developed formulation was used for delivery from a metered dose spray. Various qualitativ...
متن کاملFactors affecting the efficiency of aerosol therapy with pressurised metered-dose inhalers through plastic spacers.
AIM The main objective of this study was to compare the in vitro delivery of salbutamol from a chlorofluorocarbon(CFC)-propelled pressurised metered-dose inhaler (pMDI) versus a newly developed hydrofluoroalkane(HFA)-propelled pMDI through various spacers. In addition, we aimed to study the effect on bronchodilator response when using an optimal pMDI/spacer combination for aerosol delivery comp...
متن کاملOptimizing aerosol delivery by pressurized metered-dose inhalers.
The modern era of aerosol therapy began with the introduction of the Medihaler Epi in 1956, after a 13-year-old asthmatic told her father, an officer in the Riker company, that asthma medications should be as convenient to use as hair spray and she complained that the bulb atomizer leaked in her school bag. Since then, advances in technology have made aerosol delivery much more efficient, so th...
متن کاملBronchodilator delivery with metered-dose inhalers in mechanically-ventilated patients.
Metered-dose inhalers (MDIs) provide several advantages over nebulizers, including ease of administration, decreased cost, reliability of dosing, and freedom from contamination. However, this method of aerosol delivery has been considered ineffective in mechanically-ventilated patients because most of the aerosol deposits in the endotracheal tube and ventilator circuit. A smaller amount of aero...
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ژورنال
عنوان ژورنال: The Journal of Pediatric Pharmacology and Therapeutics
سال: 2016
ISSN: 1551-6776
DOI: 10.5863/1551-6776-21.3.247